A peptidylic inhibitor for neutralizing expanded CAG RNA-induced nucleolar stress in polyglutamine diseases. SRPKIN-1: A covalent SRPK1/2 inhibitor that potently covers VEGF from pro-angiogenic to anti-angiogenic form.
Molecular Therapy Nucleic Acids, 16, 172-185. (2019) A peptidylic inhibitor for neutralizing r( GGGGCC) exp-associated neurodegeneration in C9ALS-FTD. Target-based discovery and development of inhibitors for molecular targets in cancers and neurodegenerative diseases and investigation of the structures and mechanisms of the inhibitors.Determining the structure, function, and mechanism of proteins that involve in the regulation of pre-mRNA splicing using a multidisciplinary approach combining X-ray crystallography and cryo-EM with biochemical and biological studies.
Associate Professor, School of Life Sciences.M.Sc., University of California San Diegoī.Sc., University of California San Diego Ph.D., University of California San Diego This email address is being protected from spambots. (Lab): Rm 118, Run Run Shaw Science Building
(Office): Rm E403, Science Centre East Block